In the literature cases of stroke and transient neurological symptoms have been described after sclerotherapy for chronic Filter Cable venous disease The initial interpretation of these phenomena was that of a micro air embolism in association with a patent foramen ovale.This explanation did not always manage to justify all neurological manifestations.Recent theories have demonstrated that in the area of sclerosis, a significant amount of endothelin 1.We carried out a retrospective assessment of sclerotherapy case studies on 540 patients at ten phlebological centres to search for a relationship between the use of aminaftone (a venotropic drug with demonstrated anti-endothelin action) and the occurrence of side effects after sclerotherapy was performed.Significant reduction of side effects was Bags observed in sclerotherapy for teleangectasias and in patients with migraine history.